In 1984, shortly before his 18th birthday, Saadiq heard about tryouts in San Francisco for Sheila E.'s backing band on Prince's Parade Tour. In the mid-1990s, he adopted the last name Saadiq, which means "man of his word" in Arabic. In 1999, Saadiq's next big project became the R&B supergroup Lucy Pearl.
He produced songs for Le Toya Luckett's forthcoming second album Lady Love, released August 2009.
In 2011, Saadiq was the guitarist/bandleader for the group backing Mick Jagger for Jagger's tribute performance of the Solomon Burke R&B classic, "Everybody Needs Somebody to Love" at the 53rd Grammy Awards in Los Angeles and on CBS.
The band that accompanied the performance was Saadiq's touring band called Stone Rollin.
One of his brothers overdosed on heroin and another committed suicide because he was unable to deal with his addiction to the drug.
His sister died as a result of a car crash during a police chase in a residential neighborhood.